Ethical research practices are the foundation of credible and responsible scientific work, making the ICMR National Ethical Guidelines 2017 crucial for STEM graduates, particularly those engaged in biomedical and health sciences. These guidelines ensure that research involving human participants is conducted with integrity, fairness, and respect for individual rights. They cover essential aspects such as informed consent, privacy, confidentiality, risk-benefit analysis, and the role of Institutional Ethics Committees (IECs) in reviewing research proposals. Adherence to these principles helps prevent ethical violations, including data fabrication, plagiarism, and exploitation of vulnerable populations. Understanding these guidelines is particularly important for researchers working with clinical trials, epidemiological studies, and biotechnology innovations. Many funding agencies and journals require ethical approval before accepting research findings, making compliance with ICMR guidelines a necessity for publication and grants. Moreover, STEM graduates pursuing careers in healthcare, biotechnology, or pharmaceutical industries must be well-versed in these ethical norms to ensure regulatory compliance. Ethical research not only safeguards human rights but also enhances the credibility and social impact of scientific discoveries. By following these guidelines, researchers contribute to a culture of transparency and accountability in science, fostering trust within the global scientific community.